THE LENGTH OF A LANTIBIOTIC HINGE REGION HAS PROFOUND INFLUENCE ON ANTIMICROBIAL ACTIVITY AND HOST SPECIFICITY

The length of a lantibiotic hinge region has profound influence on antimicrobial activity and host specificity

Lantibiotics are ribosomally synthesized (methyl)lanthionine containing peptides which can efficiently inhibit the growth of Gram-positive bacteria.As lantibiotics kill bacteria efficiently and resistance to them is difficult to be obtained, they have the potential to be used in many applications, e.g.in pharmaceutical industry or food industry.Nis

read more

Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors

The goal of treatment of chronic hepatitis C is to achieve a sustained virological response, which is defined as exhibiting undetectable hepatitis C virus (HCV) RNA levels in quarks dsp serum following therapy for at least six months.However, the current treatment is only effective in 50% of patients infected with HCV genotype 1, the most prevalent

read more


Clonality analysis and IDH1 and IDH2 mutation detection in both components of dedifferentiated chondrosarcoma, implicated its monoclonal origin

Dedifferentiated chondrosarcoma (DDCS) is a highly malignant tumor that belongs voyage et cie quartier latin santal to an uncommon subtype of chondrosarcoma with a poor prognosis.Microscopically, it is composed of highly differentiated chondrosarcoma and highly malignant noncartilaginous sarcomas with an abrupt interface.The question of whether the

read more